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世界干细胞研究之父多伦多大学Till, James E. Collection詹姆斯•蒂尔教授

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世界干细胞研究之父多伦多大学詹姆斯·埃德加·蒂尔教授

加拿大生物物理学家、干细胞和癌症研究人员、多伦多大学前教授。

生于: 1931 年 8 月 25 日(84 岁),加拿大劳埃德明斯特
教育背景: 耶鲁大学, 萨斯喀彻温大学
所获奖项: 拉斯克基础医学研究奖, 盖尔德纳国际奖
蒂尔率先研究了各种哺乳动物组织的放射敏感性,包括骨髓。

他与欧内斯特?麦卡洛克共同发表了关于造血干细胞的基本生物生理学和病理生理学的论文。从1980年开始转向癌症研究。






James Edgar Till, , , (born August 25, 1931) is a University of Toronto , best known for demonstrating with the existence of .


Early work


Till was born in , Canada at , which is located on the border between and . The family farm was located north of , in ; the eastern margin of the farm was the - boundary.


He attended the University of Saskatchewan with scholarships awarded by the Company and the National Research Council, graduating with a B.Sc. in 1952 and a M.Sc. in physics in 1954. Some of his early work was conducted with , a pioneer in . Till proceeded to , where he received a Ph.D. in biophysics in 1957. He then became a post-doctoral fellow at the University of Toronto.


Stem cells


Harold Johns recruited Till to the at shortly after he completed his work at Yale. Subsequently, Till chose to work with Ernest McCulloch at the . Thus, the older physicians insight was combined with the younger physicists rigorous and thorough nature.


In the early 1960s, McCulloch and Till started a series of experiments that involved injecting bone marrow cells into irradiated mice. They observed that small raised lumps grew on the spleens of the mice, in proportion to the number of bone marrow cells injected. Till and McCulloch dubbed the lumps spleen colonies, and speculated that each lump arose from a single marrow cell: perhaps a stem cell.


In later work, Till and McCulloch were joined by graduate student Andy Becker. They cemented their stem cell theory and in 1963 published their results in . In the same year, in collaboration with , a trailblazer for molecular biology in Canada, they obtained evidence that these same marrow cells were capable of self-renewal, a crucial aspect of the functional definition of stem cells that they had formulated.


In 1969, Till became a Fellow of the .


Later career


In the 1980s Tills focus shifted, moving gradually into evaluation of cancer therapies, quality of life issues, and Internet research, including and the ethics of List mining.


Till holds the distinguished title of University Professor Emeritus at the .


Recently, Till has been a vocal proponent of to scientific publications.


Till is an editorial member of the Journal of Medical Internet Research.


Till is a founding member of the Board of Directors of the Canadian Stem Cell Foundation.


Honours


1993, awarded by the National Cancer Institute of Canada


1994, made an Officer of the


2000, made a Fellow of the


2004, inducted into the


2005, he and Ernest A. McCulloch were awarded the Albert Lasker Award for Basic Medical Research


2006, made a member of


Selected publications




 


 


 






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